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1.Title: |
Effects of (±) 3,4-Methylenedioxymethamphetamine (MDMA) on Sleep and Circadian Rhythms
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
231-238 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Toxicology
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Drug Dependence
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Behavior
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Psychopharmacology
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Cognition
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![[Full Text PDF]](../images/pdf.gif "Download Full Text PDF")
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Synopsis: |
(±) 3,4-Methylenedioxymethamphetamine (MDMA) is a popular drug of abuse and brain serotonin neurotoxin in animals and, probably, humans. Serotonin plays an important role in sleep and circadian activity and available research suggests that animals and humans previously exposed to MDMA develop lasting changes in sleep and circadian regulation. This paper will review the current literature addressing this important question and will highlight areas of future research needed to address gaps in our understanding of MDMA-induced changes in sleep regulation. |
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2.Title: |
Cocaine and Sleep: Early Abstinence
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
223-230 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Behavior
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Psychopharmacology
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Cognition
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Psychiatry
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Synopsis: |
Sleep in chronic cocaine users during the first three weeks of abstinence is reviewed and treatment implications are discussed. |
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3.Title: |
Brain Phosphorus Magnetic Resonance Spectroscopy Imaging of Sleep Homeostasis and Restoration in Drug Dependence
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Authors: |
Trksak, George H; Jensen, J. Eric ; Renshaw, Perry F.; Lukas, Scott E. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
217-222 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Psychology (Behavioral & Clinical)
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Synopsis: |
This mini-review examines the significance of studies investigating sleep physiology and behavior in drug-dependent populations. The studies reviewed evidence alterations in sleep homeostatic and restoration processes in response to sleep deprivation in drug abusing populations. A greater understanding of neural mechanisms related to the numerous reports of sleep difficulties in drug abusing populations is of particular importance based upon the potential influence of sleep loss in perpetuating drug-taking behaviors or relapse in drug abstinence. |
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4.Title: |
Polysomnographic Sleep Dysregulation in Cocaine Dependence
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Authors: |
Valladares, Edwin M.; Irwin, Michael R. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
213-216 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Abstract |
Insomnia and sleep disturbance are associated with declines in health functioning, along
with increases in mortality risk. Given the prominence of reported sleep disturbance in
cocaine-dependent subjects and persistence into recovery, und ...
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5.Title: |
Drugs of Abuse Can Entrain Circadian Rhythms
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
203-212 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Behavior
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Motor Processes
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Synopsis: |
A variety of drugs of abuse entrain a circadian rhythm of locomotor activity that precedes daily drug administration. These rhythms arise in the absence of external cues predicting drug, and are independent of the light-entrained rest/activity cycle. Drugs shown to entrain these rhythms include psychostimulants (methamphetamine, cocaine, and nicotine), opiates (fentanyl), and sedative/hypnotics (alcohol); saline and haloperidol do not. We hypothesize that these activity bursts reflect anticipatory somatic states, which increase drug seeking, sensitivity, and tolerance, thereby contributing to drug abuse and addiction. |
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6.Title: |
Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
194-202 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Synopsis: |
This is a mini-review describing the influence of the circadian genes on drug addiction, with an emphasis on the regulation of dopaminergic transmission by these genes and how this might lead to changes in drug-induced responses. |
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7.Title: |
Sleep, Circadian Rhythm, and Drug Abuse
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Authors: |
Gordon, Hal W. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
191-193 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Editorial |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Abstract |
The biology and neurobiology underlying the sleep disturbance is inextricably interwoven with the pathophysiology of the disease process itself. So intertwined are these co-occurring conditions that it is often impossible to determine cause ...
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8.Title: |
P-Body Components, microRNA Regulation, and Synaptic Plasticity
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Authors: |
Hillebrand, Jens ; Barbee, Scott A.; Ramaswami, Mani |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
178-190 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Abstract |
What is the protein apparatus required for microRNA (miRNA) function and translational repression in neurons? This article reviews our recent work on Me31B, a conserved P-body protein present on Staufen-containing neuronal and maternal ribo ...
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9.Title: |
MicroRNAs in Vertebrate Synapse Development
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
167-177 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Synopsis: |
We recently identified microRNAs as crucial regulators of local protein synthesis and synaptic plasticity. This novel mode of regulation of gene expression in post-mitotic neurons might have important implications for the understanding of learning, memory, and a variety of neurological diseases. |
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10.Title: |
MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology
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Authors: |
Krichevsky, Anna M. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
155-166 |
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Date of publication: |
2/11/2007 |
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Article Type: |
Mini-Review Article |
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Handling Editor: |
Shurtleff, D./Ferre, S. |
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Domains: |
Neuroscience
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Drug Dependence
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Abstract |
Contemporary biology has been revolutionized by a recently discovered class of small regulatory RNA molecules, microRNAs (miRNAs). Missed by researchers for decades due to their tiny size, usually mapping to non-protein-coding regions of ge ...
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