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  71.Title:

Progressive Familial Intrahepatic Cholestasis (PFIC) Type 3 in Two Sicilian Siblings of Nonconsanguineous Parents

  Authors:

Crupi, Isodiana  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1065-1066 
  Date of publication:

14/6/2010 
  Article Type:

Letter to the Editor 
  Handling Editor:

Raj K. Goyal 
  Domains: Cell Biology , Gastroenterology , Cell Signaling , Genes & Genomics , Biochemistry & Molecular Biology  
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  Synopsis: Progressive familial intrahepatic cholestasis (PFIC) is a group of autosomal-recessive disorders. Genomic DNA analysis of two brothers, affected with PFIC type 3, show homozygosity for mutations in the human MDR3 gene with heterozygosity of nonconsanguineous parents. The presence of mutations in the human MDR3 gene has been previously described only in siblings of consanguineous parents. 
  72.Title:

Lipoxin and Aspirin-Triggered Lipoxins

  Authors:

Romano, Mario  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1048-1064 
  Date of publication:

2/6/2010 
  Article Type:

Review Article 
  Handling Editor:

Joan Clària 
  Domains: Cell Biology , Pharmacology , Drug Discovery , Cardiovascular Biology , Experimental Medicine , Gastroenterology , Sensation & Perception , Cell Signaling , Gene, Molecular & Cell Therapy , Immunology & Inflammation , Microbiology , Pulmonology & Pulmonary Pathology , Biochemistry & Molecular Biology  
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  Synopsis: This article reviews the available literature on lipoxins and aspirin-triggered lipoxins (ATL). These eicosanoids are emerging as pivotal break signals of inflammation and promoters of resolution. Their biosynthetic pathways, bioactions, and involvement in human disease are discussed, as well as their potential use as a new class of anti-inflammatory drugs. 
  73.Title:

Molecular Circuits of Resolution in the Eye

  Authors:

Liclican, Elvira L; Gronert, Karsten  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1029-1047 
  Date of publication:

1/6/2010 
  Article Type:

Review Article 
  Handling Editor:

Joan Clària 
  Domains: Neuroscience , Cell Biology , Cardiovascular Biology , Cell Signaling , Immunology & Inflammation , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: Execution of a perfectly balanced acute inflammatory/reparative response is nowhere as critical and conserved as in the delicate visual axis, as uncontrolled inflammation impairs vision and leads to blindness. In this regard, lipid autacoid circuits have emerged as key components of endogenous pathways that preserve ocular function and limit the sequelae of ocular injury. This review summarizes the current state of the field regarding the protective endogenous lipid circuits in the ocular/inflammatory response. 
  74.Title:

Midregion PTHrP and Human Breast Cancer Cells

  Authors:

Luparello, Claudio  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1016-1028 
  Date of publication:

1/6/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Martin Goette 
  Domains: Oncology , Cell Biology , Endocrinology , Toxicology , Cell Signaling , Genes & Genomics , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: PTHrP is a polyhormone undergoing proteolytic processing and its midregion domain, (38-94)-amide, causes striking toxicity and accelerates death of breast cancer cells in vitro and in vivo. Midregion PTHrP can also be imported in cell nucleoplasm and in vitro it can bind chromatin of metaphase spread preparations and also isolated oligonucleotides, thereby appearing endowed with a putative transcription factor–like DNA-binding ability. This review summarizes the data so far produced in this field. 
  75.Title:

Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

  Authors:

Chan, Chia-Hsin ; Lee, Szu-Wei ; Wang, Jing ; Lin, Hui-Kuan  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1001-1015 
  Date of publication:

1/6/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Adele Murrell 
  Domains: Oncology , Cell Biology , Cell Cycle , Cell Signaling , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Overexpression of Skp2 is associated with a variety of human cancers, indicating that Skp2 may contribute to the development of human cancers. The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers. 
  76.Title:

Artificial Organelles: Digital Microfluidic Platform for Proteoglycan and Glycoprotein Biosynthesis

  Authors:

Martin, Jeffrey G.; Beaudet, Julie M.; Dordick, Jonathan S.; Linhardt, Robert J. 
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

997-1000 
  Date of publication:

1/6/2010 
  Article Type:

Directions in Science 
  Handling Editor:

Martin Goette 
  Domains: Cell Biology , Methods & Protocols , Biomimetics , Cell Signaling , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: Using the technologies of digital microfluidics, recombinant enzyme technology, and magnetic nanoparticles, we have created a functional prototype of an artificial Golgi organelle. Work is currently under way to develop and integrate an artificial endoplasmic reticulum for on-chip synthesis of proteoglycans and glycoproteins. 
  77.Title:

Selenium Supplementation does not Decrease Thyroid Peroxidase Antibody Concentration in Children and Adolescents with Autoimmune Thyroiditis

  Authors:

Bonfig, Walter ; Gaertner, Roland ; Schmidt, Heinrich  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

990-996 
  Date of publication:

1/6/2010 
  Article Type:

Research Article 
  Handling Editor:

Joav Merrick 
  Domains: Endocrinology , Nutrition , Child Health & Human Development , Immunology & Inflammation  
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  Synopsis: We present unique data of selenium supplementation in children and adolescents with autoimmune thyroiditis. The effect of selenium supplementation in this autoimmune condition has not been studied in children and adolescents so far. We feel that publishing negative results is important, especially in controversial therapies. In addition, we present data on the prevalence of goiter in autoimmune thyroiditis and on levothyroxine doses needed to treat autoimmune hypothyroidism. Such data do not exist in the literature so far. 
  78.Title:

Atrial Septal Aneurysm: A Major Diagnostic Clue for a Patent Foramen Ovale

  Authors:

Nia, Amir M; Gassanov, Natig ; Caglayan, Evren ; Er, Fikret  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

988-989 
  Date of publication:

1/6/2010 
  Article Type:

Clinical Images 
  Handling Editor:

Daniel Batlle 
  Domains: Cardiovascular Biology , Imaging , Medicine , Clinical Images  
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  Synopsis: The ultrasound image of the heart illustrates a typical and characteristic finding of an interatrial aneurysm (ASA). An ASA is often associated with an interatrial defect, as in this case. 
  79.Title:

Anal Carcinoma in an HIV-Infected Woman

  Authors:

Sendagorta, Elena ; Herranz, Pedro ; Guadalajara, Héctor ; Zamora, Francisco ; Gonzalez, Juan  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

986-987 
  Date of publication:

1/6/2010 
  Article Type:

Clinical Images 
  Handling Editor:

Daniel Batlle 
  Domains: Oncology , Medical Care , Microbiology , Medicine , Clinical Images  
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  Synopsis: We present a case of anal cancer in an HIV-infected woman. 
  80.Title:

Distribution, Levels, and Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in Some Water Bodies along the Coastal Belt of Ghana

  Authors:

Essumang, David Kofi 
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

972-985 
  Date of publication:

1/6/2010 
  Article Type:

Research Article 
  Handling Editor:

Lars Sonesten 
  Domains: Environmental Chemistry , Environmental Management & Policy , Toxicology , Aquatic Toxicology  
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  Synopsis: Cancer cases among the population in the developing world are on the increase, which may be linked to exposures to xenobiotics. Solid waste dumps are scattered along the banks of water bodies with occasional burning in an attempt to reduce the waste size, which may introduce polycyclic aromatic hydrocarbons (PAHs) into these water bodies. This study investigated the levels, distribution, and risk assessment of PAHs in some water bodies along the coastal belt of Ghana. 

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