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1.Title: |
Cardiac Development
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
855-858 |
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Date of publication: |
31/08/2008 |
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Article Type: |
Editorial |
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Domains: |
Cardiovascular Biology
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Development & Embryology
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![[Full Text PDF]](../images/pdf.gif "Download Full Text PDF")
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Synopsis: |
The first functional organ in the embryo is the heart and cardiovascular system. It is small wonder that the complexity of heart development often results in malformations, the largest group of congenital anomalies. Many nonlethal cardiovascular anomalies are encountered that need clinical intervention to improve quality of life, providing a huge cost factor for society. The special issue on Cardiac Development of TheScientificWorldJOURNAL is devoted to many of these mechanisms and interactions, starting as early as the precardiac mesoderm. |
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2.Title: |
Development of the Cardiac Conduction System and the Possible Relation to Predilection Sites of Arrhythmogenesis
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Authors: |
Jongbloed, M.R.M. ; Mahtab, E.A.F. ; Blom, N.A. ; Schalij, M.J. ; Gittenberger-de Groot, A.C. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
239-269 |
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Date of publication: |
3/3/2008 |
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Article Type: |
Review Article |
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Handling Editor: |
Robert E. Poelmann |
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Domains: |
Neuroscience
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Cardiovascular Biology
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Motility
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Development & Embryology
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Abstract |
The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different ...
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3.Title: |
Fluid Shear Stress and Inner Curvature Remodeling of the Embryonic Heart. Choosing the Right Lane!
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
212-222 |
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Date of publication: |
25/2/2008 |
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Article Type: |
Review Article |
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Handling Editor: |
Robert E. Poelmann |
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Domains: |
Cardiovascular Biology
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Biophysics
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Motor Processes
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Motility
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Cell Signaling
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Development & Embryology
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Intercellular Communication
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Abstract |
Cardiovascular development is directed or modulated by genetic and epigenetic factors. The latter include blood flow-related shear stress and blood pressure-related circumferential strain. This review focuses on shear stress and its effects ...
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4.Title: |
The Expanding Role for Retinoid Signaling in Heart Development
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
194-211 |
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Date of publication: |
25/2/2008 |
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Article Type: |
Review Article |
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Handling Editor: |
Robert E. Poelmann |
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Domains: |
Cell Biology
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Toxicology
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Pharmacology
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Cardiovascular Biology
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Cell Signaling
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Development & Embryology
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Genes & Genomics
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Proteins & Proteomics
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Intercellular Communication
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Abstract |
The importance of retinoid signaling during cardiac development has long been appreciated, but recently has become a rapidly expanding field of research. Experiments performed over 50 years ago showed that too much or too little maternal in ...
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5.Title: |
Origin, Fate, and Function of Epicardium-Derived Cells (EPDCs) in Normal and Abnormal Cardiac Development
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Authors: |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1777-1798 |
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Date of publication: |
12/11/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
David L. Tannahill |
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Domains: |
Neuroscience
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Cell Fate & Determination
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Cell Biology
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Cardiovascular Biology
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Cell Signaling
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Development & Embryology
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Genes & Genomics
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Proteins & Proteomics
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Synopsis: |
Epicardium-derived cells are important for coronary formation, for development of the atrioventricular valves, the fibrous heart skeleton, myocardial architecture and for development of the Purkinje fibers of cardiac conduction system. We propose an additional role for EPDCs in cardiac looping, show that Ets-1 and Ets-2 transcription factors are crucial for EPDC development, and discuss how EPDCs are implied in congenital heart defects in which valves, fibrous heart skeleton and ventricular wall morphology are affected. |
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6.Title: |
Cardiovascular Development and the Colonizing Cardiac Neural Crest Lineage
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Authors: |
Snider, Paige ; Olaopa, Michael ; Firulli, Anthony B.; Conway, Simon J. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1090-1113 |
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Date of publication: |
3/7/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Robert E. Poelmann |
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Domains: |
Neuroscience
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Cell Fate & Determination
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Cell Biology
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Cardiovascular Biology
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Imaging
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Cell Signaling
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Development & Embryology
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Genes & Genomics
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Intercellular Communication
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Abstract |
Although it is well established that transgenic manipulation of mammalian neural crest–related gene expression and microsurgical removal of premigratory chicken and Xenopus embryonic cardiac neural crest progenitors results in a wide spectr ...
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7.Title: |
A Role for the Cytoskeleton in Heart Looping
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Authors: |
Linask, Kersti K.; VanAuker, Michael |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
280-298 |
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Date of publication: |
19/2/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Robert E. Poelmann |
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Domains: |
Cell Biology
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Cardiovascular Biology
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Cell Signaling
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Development & Embryology
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Genes & Genomics
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Synopsis: |
Over the past 10 years, key genes involved in specification of left-right laterality pathways in the embryo have been defined. The read-out for misexpression of laterality genes is usually the direction of heart looping. The question of how dextral looping direction occurred mechanistically and how the heart tube bends remains unknown. It is becoming clear from our experiments and those of others that left-right differences in cell proliferation in the second heart field (anterior heart field) drives the dextral direction. Evidence is accumulating that the cytoskeleton is at the center of laterality, and the bending and rotational forces associated with heart looping. If laterality pathways are modulated upstream, the cytoskeleton, including nonmuscle myosin II (NMHC-II), is altered downstream within the cardiomyocytes, leading to looping abnormalities. The cytoskeleton is associated with important mechanosensing and signaling pathways in cell biology and development. The initiation of blood flow during the looping period and the inherent stresses associated with increasing volumes of blood flowing into the heart may help to potentiate the process. In recent years, the steps involved in this central and complex process of heart development that is the basis of numerous congenital heart defects are being unraveled. |
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8.Title: |
Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart
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Authors: |
Eisenberg, Leonard M.; Eisenberg, Carol A. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
161-176 |
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Date of publication: |
2/2/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Robert E. Poelmann |
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Domains: |
Cell Fate & Determination
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Cell Biology
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Cardiovascular Biology
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Cell Signaling
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Development & Embryology
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Biochemistry & Molecular Biology
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Abstract |
Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathwa ...
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