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1.Title: |
Endogenous Receptor Agonists: Resolving Inflammation
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Authors: |
Bannenberg, Gerhard ; Arita, Makoto ; Serhan, Charles N. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1440-1462 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cell Signaling
,
Immunology & Inflammation
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Controlled resolution or the physiologic resolution of a well-orchestrated inflammatory response at the tissue level is essential to return to homeostasis. A comprehensive understanding of the cellular and molecular events that control the ...
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2.Title: |
Leukotriene Receptors: Crucial Components in Vascular Inflammation
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Authors: |
Bäck, Magnus |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1422-1439 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cardiovascular Biology
,
Cell Signaling
,
Immunology & Inflammation
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
The accumulation of immune cells during vascular inflammation leads to formation of leukotrienes (LTs). While macrophages represent a major source of LT biosynthesis in the proximity of the vascular wall, activated T lymphocytes may, in add ...
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3.Title: |
The Role of Leukotriene Receptor Signaling in Inflammation and Cancer
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Authors: |
Massoumi, Ramin ; Sjölander, Anita |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1413-1421 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Oncology
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Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cell Signaling
,
Immunology & Inflammation
,
Proteins & Proteomics
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate ...
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4.Title: |
Lipoxin Receptors
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Authors: |
Romano, Mario ; Recchia, Irene ; Recchiuti, Antonio |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1393-1412 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cell Signaling
,
Immunology & Inflammation
,
Proteins & Proteomics
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti-inflammatory properties, LXA4 and LXB4 being the main components of this series. LXs are generated by cooperation between 5-li ...
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5.Title: |
Cysteinyl-Leukotriene Receptors and Cellular Signals
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Authors: |
Rovati, G. Enrico ; Capra, Valérie |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1375-1392 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cell Signaling
,
Immunology & Inflammation
,
Proteins & Proteomics
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Cysteinyl-leukotrienes (cysteinyl-LTs) exert a range of proinflammatory effects, such as constriction of airways and vascular smooth muscle, increase of endothelial cell permeability leading to plasma exudation and edema, and enhanced mucus ...
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6.Title: |
Prostanoid Receptors in the Human Vascular Wall
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Authors: |
Norel, Xavier |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1359-1374 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cardiovascular Biology
,
Cell Signaling
,
Immunology & Inflammation
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
The mechanisms involved in vascular homeostasis and disease are mostly dependent on the interactions between blood, vascular smooth muscle, and endothelial cells. There is an accumulation of evidence for the involvement of prostanoids, the ...
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7.Title: |
Cytokine-Leukotriene Receptor Interactions
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Authors: |
Rola-Pleszczynski, Marek ; Stankova, Jana |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1348-1358 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Cell Signaling
,
Immunology & Inflammation
,
Proteins & Proteomics
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interactio ...
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8.Title: |
Prostaglandin Receptor Signaling in Disease
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Authors: |
Matsuoka, Toshiyuki ; Narumiya, Shuh |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1329-1347 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
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Pathology
,
Pharmacology
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Drug Discovery
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Experimental Medicine
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Gastroenterology
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Cell Signaling
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Clinical & Medicinal Chemistry
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Immunology & Inflammation
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Microbiology
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Proteins & Proteomics
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Intercellular Communication
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Biochemistry & Molecular Biology
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Abstract |
Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2á, PGI2, and TXA2. They are released outside of the cells im ...
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9.Title: |
Regulation of Immune Cells by Eicosanoid Receptors
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Authors: |
Kim, Nancy ; Luster, Andrew D. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1307-1328 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Handling Editor: |
Charles Brink |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Experimental Medicine
,
Cell Signaling
,
Immunology & Inflammation
,
Proteins & Proteomics
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Eicosanoids are potent, bioactive, lipid mediators that regulate important components of the immune response, including defense against infection, ischemia, and injury, as well as instigating and perpetuating autoimmune and inflammatory con ...
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10.Title: |
Structural Manipulation of Eicosanoid Receptors and Cellular Signaling
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Authors: |
Brink, Charles |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
1285-1306 |
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Date of publication: |
1/9/2007 |
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Article Type: |
Review Article |
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Domains: |
Cell Biology
,
Pharmacology
,
Drug Discovery
,
Experimental Medicine
,
Cell Signaling
,
Immunology & Inflammation
,
Proteins & Proteomics
,
Intercellular Communication
,
Biochemistry & Molecular Biology
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Abstract |
Eicosanoids are lipid mediators derived from the metabolism of arachidonic acid. These agents are locally released and activate different cell membrane receptors, and the latter are part of the G-protein coupled receptor family. While activ ...
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