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1.Title: |
HIGH-THROUGHPUT PROTEIN EXPRESSION AND PURIFICATION FOR PROTEOMICS RESEARCH
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Authors: |
Doyle, Sharon A.; Murphy, Michael ; Primus, Jennifer ; Richardson, Paul ; Hawkins, Trevor |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
146-147 |
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Date of publication: |
4/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Full insight into the control of genomic sequences over many biological processes requires the analysis of the protein products. Only through the analysis of proteins on a genomic scale can we begin to understand the complexities encoded in ...
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2.Title: |
SOME ASPECTS OF DNA-ETBR INTERACTION PECULIARITIES
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Authors: |
Vardevanyan, Poghos O.; Antonyan, Ara P.; Minasbekyan, Lia A.; Karapetyan, Armen T. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
144-145 |
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Date of publication: |
3/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Comparision of theoretical and experimental data of ethidium bromide (EtBr) binding to DNA suggested that this ligand can complex with DNA by several different types of interactions[1,2]. The dependence of temperature transition width from ...
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3.Title: |
STRUCTURAL INSIGHT INTO THE MECHANISMS OF TARGETING AND SIGNALING OF FOCAL ADHESION KINAS
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Authors: |
Liu, Gaohua ; Guibao, Cristina D.; Zheng, Jie |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
142-143 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indis ...
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4.Title: |
A NEW MONOCLONAL ANTIBODY DEMONSTRATES THAT MUC4, THE INTRAMEMBRANE LIGAND FOR ErbB2/HER2/Neu, IS OVEREXPRESSED IN MULTIPLE CARCINOMAS
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Authors: |
Zhang, Jin ; Carraway, Kermit L. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
140-141 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
MUC4, a membrane mucin, is expressed in multiple epithelia. Several studies have suggested that MUC4 gene is overexpressed in human carcinomas[1]. Human MUC4 was originally cloned and sequenced from airway cDNA library[2]. Most of the funct ...
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5.Title: |
EXPRESSION OF HEME OXYGENASE-1 MEDIATED BY A PROTEIN TRANSDUCTION DOMAIN PROTECTS INSULIN PRODUCING CELLS FROM CYTOKINE- INDUCED CYTOTOXICITY
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Authors: |
Ribeiro, Melina ; Klein, Dagmar ; Pileggi, Antonello ; Molano, R. Damaris; Fraker, CHristopher ; Ricordi, Camillo ; Inverardi, Luca ; Pastori, Ricardo L. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
138-139 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Microsomal Heme Oxygenase-1 (HO-1) has been identified as a ubiquitous stress protein induced in many cell types by various stimulants such as hemolysis, inflammatory agents, oxidative stress, heat shock, and growth factors[1]. HO-1 is the ...
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6.Title: |
THE FOUR-STATE EQUILIBRIUM UNFOLDING OF A scFv ANTIBODY FRAGMENT
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Authors: |
Pedroso, Idolka ; Irun, María P.; Machicado, Claudia ; Sancho, Javier |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
136-137 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Single chain Fv fragments (scFv) are interesting alternatives to the use of whole antibody molecules. We describe here an equilibrium intermediate of the thermal and urea unfolding that may compromise the stability of this class of molecule ...
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7.Title: |
THE USE OF ANTISENSE-MEDIATED INHIBITION TO DELINEATE THE ROLE OF INFLAMMATORY AGENTS IN THE PATHOPHYSIOLOGY OF SPINAL CORD INJURY
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Authors: |
Pearse, Damien D.; Pereira, Francisco C.; Chatzipanteli, Katina ; Dietrich, Francisco W. Dalton; Bunge, Mary Bartlett |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
133-135 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Injuries to the central nervous system (CNS) usually lead to a potent and acute inflammatory response[1]. During this period, glia and immune cells respond to chemical cues associated with the debris of lysed neurons, disrupted axons, and a ...
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8.Title: |
PROTEIN MISFOLDING AND HUMAN DISEASE
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Authors: |
Dobson, Christopher |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
132-132 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Protein folding is perhaps the most fundamental process associated with the generation of functional structures in biology. There has been considerable progress in the last few years in understanding the underlying principles that govern th ...
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9.Title: |
MOLECULAR BREEDING OF GENES, PATHWAYS AND GENOMES BY DNA SHUFFLING
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Authors: |
Stemmer, WIllem P.C. |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
130-131 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Genomics is yielding a wealth of sequence and functional information that impacts all areas of biotechnology, including pharmaceuticals, vaccines, chemicals/enzymes, and agriculture. However, developing products from these novel genes and p ...
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10.Title: |
ENGINEERING POLYKETIDE SYNTHASES
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Authors: |
Katz, Leonard |
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Journal: |
TheScientificWorldJOURNAL |
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Page Range: |
127-129 |
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Date of publication: |
2/01/2002 |
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Article Type: |
Short Report |
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Domains: |
Gene, Molecular & Cell Therapy
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Abstract |
Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyke ...
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