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Title: |
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Complex Regional Pain Syndrome (CRPS/RSD) and Neuropathic Pain: Role of Intravenous Bisphosphonates as Analgesics |
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Authors: |
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Yanow, Jen ; Pappagallo, Marco ; Pillai, Letha |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2008 |
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Volume: |
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8 |
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Page Range: |
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229-236 |
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Article Type: |
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Review Article |
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Handling Editor: |
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George Siegel |
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Domains: |
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Bone Biology
,
Pharmacology
,
Drug Discovery
,
Neurology
,
Anesthesiology
,
Medicine
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DOI: |
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10.1100/tsw.2008.33 |
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 ?
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abnormal bone -
analgesics -
animal model -
animal models -
bisphosphonates -
bone metabolism -
bone pain -
central nervous system -
clinical trials -
complex regional pain syndrome -
hallmark -
hypersensitivity -
medical literature -
pain pathways -
pathologic conditions -
pathophysiology -
preclinical studies -
regional pain syndrome -
rsd -
sequela
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Keywords: |
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CRPS/RSD, neuropathic pain, CRPS 1, CRPS 2, RSD, causalgia, bisphosphonates |
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Abstract |
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Neuropathic pain is a sequela of dysfunction, injuries, or diseases of the peripheral and/or central nervous system pain pathways, which has historically been extremely difficult to treat. Complex regional pain syndrome (CRPS) types 1 and 2 are neuropathic pain conditions that have a long history in the medical literature but whose pathophysiology remains elusive and whose available treatment options remain few. While an exact animal model for CRPS doesn't yet exist, there are several animal models of neuropathic pain that develop behaviors of hypersensitivity, one of the hallmark signs of neuropathic pain in humans.
Bisphosphonates have been used for pathologic conditions associated with abnormal bone metabolism, such as osteoporosis, Paget’s disease and cancer-related bone pain for many years. More recently, results of clinical trials have indicated the potential role of bisphosphonates in the treatment of CRPS/RSD.
In this paper we will review the preclinical studies regarding the use of bisphosphonates as analgesics in animal models of neuropathic pain, and also summarize the clinical trials that have been done to date. We will give an overview of bisphosphonate pharmacology and discuss several potential mechanisms by which bisphosphonates may be analgesic in CRPS/RSD and bone pain of noncancer origin. |
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| Comments Received |
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deborah a fisher
Posted 14th January 2010 |
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looking for updated info on bisphosphonates in treating crps |
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Naschmil Pollmann
Posted 5th November 2009 |
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Hello, I am a paintherapist often confronted with CRPS. I often have a problem with finding the proper dosage. Could you help me and ship me the full article? |
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