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Title: |
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White Matter Lesions and Cognitive Impairment as Silent Cerebral Disease in Hypertension |
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Authors: |
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Sierra, Cristina ; Coca, Antonio |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2006 |
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Volume: |
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6 |
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Page Range: |
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494-501 |
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Article Type: |
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Review Article |
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Handling Editor: |
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Daniel Batlle |
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Domains: |
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Nephrology
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Cardiovascular Biology
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Cognition
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Neurology
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Imaging
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DOI: |
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10.1100/tsw.2006.99 |
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Keywords: |
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essential hypertension, cerebral white matter lesions, cognitive function, target organ damage, magnetic resonance imaging |
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Abstract |
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Although the pathogenesis and clinical significance of cerebral white matter lesions remain controversial, it is well established that age and hypertension are the most important factors related to the presence of these lesions. Hypertension is known to be the most important factor for developing stroke and vascular dementia. In addition, the presence of cerebral white matter lesions is an important prognostic factor for the development of stroke, and also for cognitive impairment and dementia. The mechanisms underlying hypertension-related cognitive changes are complex and are not yet fully understood. Correlations between cerebral white matter lesions and elevated blood pressure provide indirect evidence that structural and functional changes in the brain over time may lead to lowered cognitive functioning when blood pressure control is poor or lacking.
Some authors have suggested that the presence of white matter lesions in hypertensive patients could be considered an early marker of brain damage.
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| Comments Received |
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judi bricher
Posted 16th February 2007 |
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Feb. 07 I had a MRi which neurologist stated was bad and I have white matter disease with the brain of someone in 70's. I would appreciate individual info on how they are impacted by WMD.and how long they have had it. I also just had a stroke. I am 62. |
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Susan Kramss
Posted 19th August 2006 |
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I've been through my third MRI, a MRA, ultrsound of my heart, bloodwork, full physical and this is what we know. I have mysterious lesions in the anterior frontal lobes of my brain that do not enhanse, that are coming and going without rhyme or reason and that other than memory loss, occasional loss of balance, and migraines, I'm as healthy as a horse. My BP is perfect and as far the the memory loss goes, we know it began, as well as these lesions when I under went a short series of ECT treatments for bipolar. I'm now recovered from that, but I'm driving my neurologist crazy. He says I should leave my brain to medical science. Any thoughts? |
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Anne Vindenes Allen
Posted 8th August 2006 |
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TSW is pleased to introduce the new TSW article blog as a service to authors and readers. I should like to take this opportunity of thanking the authors of this paper as the first; we hope in time many useful additional insights will be gleaned from comments made on this page. |
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Nancy Sorrells
Posted 29th July 2006 |
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I just received an MRI of my brain because of extreme dizziness, nausea and unsteady gait. The MRI shows scattered areas of T2 hyperintensity in the periventricular and subcortical white matter bilaterally. Non-speciic lesions My neurologist has referred me to an ENT. Shouldn't I see a cardiologist? Thank you |
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