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Title: |
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Cardiac Development |
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Authors: |
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Poelmann, Robert E.; Gittenberger-de Groot, Adriana C. |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2008 |
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Volume: |
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8 |
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Page Range: |
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855-858 |
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Article Type: |
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Editorial |
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Domains: |
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Cardiovascular Biology
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Development & Embryology
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DOI: |
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10.1100/tsw.2008.102 |
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Synopsis: |
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The first functional organ in the embryo is the heart and cardiovascular system. It is small wonder that the complexity of heart development often results in malformations, the largest group of congenital anomalies. Many nonlethal cardiovascular anomalies are encountered that need clinical intervention to improve quality of life, providing a huge cost factor for society. The special issue on Cardiac Development of TheScientificWorldJOURNAL is devoted to many of these mechanisms and interactions, starting as early as the precardiac mesoderm. |
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Keywords: |
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cardiac development |
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Abstract |
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The development of the cardiovascular system is a very intriguing issue as it concerns the first functional organ in the embryo. In nearly 50% of prenatally lethal mouse knock-outs, the cardiovascular/hemopoietic system is affected, underscoring the importance for embryo survival. It is small wonder that the complexity of heart development often results in malformations, the largest group of congenital anomalies. Many nonlethal cardiovascular anomalies are encountered that nevertheless need clinical intervention to improve quality of life, providing a huge cost factor for society. The special issue on Cardiac Development of TheScientificWorldJOURNAL is devoted to many of these mechanisms and interactions, starting as early as the precardiac mesoderm. Both intrinsic and extrinsic factors determine the development of the cardiovascular system. These include Wnt and RA signaling; the involvement of extracardiac cell populations, such as neural crest and proepicardiac cells; the origin of the conduction system; and physical aspects, such as hemodynamic forces and material properties, including the role of the cytoskeleton in mechanotransduction. |
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