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Title: |
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Nephrotoxicity of Mala Fide Melamine: Modern Era Milk Scandal |
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Authors: |
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Lattupalli, Rakesh ; Kolluru, Anuradha ; Yee, Jerry |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2008 |
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Volume: |
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8 |
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Page Range: |
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949-950 |
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Article Type: |
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Commentary |
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Handling Editor: |
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Graham V Lees |
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Domains: |
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Nephrology
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Toxicology
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Nutrition
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Analytical Chemistry
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DOI: |
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10.1100/tsw.2008.134 |
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Synopsis: |
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Nephrotoxicity of melamine was first suggested in pets leading to pet food recall in 2007. Melamine was deemed a very low human risk, until recent reports of acute renal failure from melamine adulterated milk in China. Melamine allows for fraudulent dilution of milk by inflating protein levels due to its high nitrogen content. Exact pathophysiology linking melamine to kidney disease is unclear. It is advisable to avoid melamine until we gain a more scientific understanding of this new entity in humans. |
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Keywords: |
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melamine, cyanuric acid, nephrotoxicity, kidney stones, nephrolithiasis, milk, China |
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Abstract |
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The major pet food recall in 2007 from acute renal failure in cats and dogs was attributed to nephrolithiasis from melamine. High nitrogen content of melamine facilitates its illicit use as dietary non-protein nitrogen. Melamine was deemed a very low human risk until recent reports of acute renal failure from melamine adulterated milk in China. The exact pathophysiology linking melamine to kidney disease is unclear. Affected animals showed crystal deposition. Cyanuric acid as an additional cofactor has been proposed in animals. While we await better scientific understanding of this entity in humans, it is advisable to avoid melamine which is not a bona fide nutritional protein but a mala fide one. |
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veena.r
Posted 16th December 2008 |
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nice topic |
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